MOTS-C

MOTS-C is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA. It is catalogued here as a laboratory reference material for controlled mitochondrial and metabolic-signalling research. It is supplied strictly for laboratory research use — not for human or veterinary use.

Published laboratory research examines MOTS-C as a regulator of AMP-activated protein kinase (AMPK) signalling, with endpoints covering folate-methionine cycle flux, glucose-uptake and GLUT4 translocation markers, fatty-acid oxidation, mitochondrial biogenesis via PGC-1α, and nuclear translocation to antioxidant-response gene targets. These are experimental measurements in cell and animal research models only; no medical, therapeutic, or human-use outcome is described or implied.

Unlike peptides encoded in nuclear DNA, MOTS-C is translated from a short open reading frame inside the mitochondrial genome using the mitochondrial genetic code. That origin is what places it in the mitochondrial-derived peptide (MDP) family and makes it a common reference material in mitochondrial-signalling literature.

SS-31 binds cardiolipin on the inner mitochondrial membrane and is studied for electron-transport-chain architecture endpoints. MOTS-C is a soluble signalling peptide studied through AMPK activation and nuclear gene-expression endpoints. The two are mechanistically distinct research materials and are listed separately in the catalog.

Two third-party analytical reports from Janoshik Analytical (June 2026), covering MOTS-C and MOTS-C 10mg, are on file. Batch-level documentation can be searched in the public COA lookup, and the transparency page explains the identity, purity, and documentation framework applied to every batch.

Each batch is tested against a ≥99% purity specification by HPLC with identity confirmation by mass spectrometry, consistent with the published testing standards. Batch documentation is released with orders and indexed in the COA lookup.

MOTS-C is supplied as a lyophilized powder in sealed glass vials in 5 mg, 10 mg, 20 mg, 30 mg, and 40 mg formats, each carrying a batch identifier that maps to its analytical documentation.

Store the sealed lyophilized vial refrigerated, dry, and protected from light, and follow the batch documentation supplied with the vial. Orders ship domestically from the USA with tracked delivery. All material is intended strictly for controlled laboratory research.